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Abstract: Neuroplasticity is an important feature of respiratory control and critical for life, as this allows for adjustments to breathing to fit our metabolic needs across development, disease, injury, and aging. Nicotine is a highly addictive recreational drug that modulates neuronal excitability and plasticity, and the impact of in utero nicotine exposure on the development and function of central networks that control breathing have been extensively studied. Conversely, despite the widespread use of tobacco and nicotine products, we know little about how chronic nicotine exposure impacts breathing control in adulthood. This seminar will highlight some of the ways the Wollman lab studies nicotine-mediated plasticity of respiratory control by giving an overview of past and current research projects including 1) work in neonatal rats showing that in utero nicotine exposure modulates fast-synaptic transmission, indicating a potential mechanism for Sudden Infant Death Syndrome, and 2) Dr. Wollman’s current NIH funded research, which is the first to show the detrimental effects of acute nicotine withdrawal on respiratory chemoreflex control in adult rats.

Wollman Respiratory Physiology Laboratory

Dr. Carly S. Cox is currently a Science Policy Analyst for the Institute of Defense Analyses, a federally-funded group that advises Congress on policy pertaining to biotechnology and biosecurity. Carly earned her Bachelor's degree in Biochemistry and Molecular Biology at the University of Georgia, then earned her Master's as well as her Doctorate degree in Molecular, Cellular, and Developmental Biology at Yale University. She started out her career as an intern for Connecticut Congresswoman Rosa DeLauro in her 14th term, and served as a point of contact between DeLauro and constituents as well as government agencies. Since then, she has worked as a science policy advocate for several non-profits, including Research! America, a medical and health research advocacy group aimed at educating and lobbying for policy that supports public health, and the Council on Strategic Risks, a non-partisan group focused on advocating for U.S. biosecurity and biodefense. Carly has lived all over the east coast and currently lives in Washington D.C. 

Food and beverages will be provided 

ION Fall Rotation Talks

Tuesday, December 10, 2024

2:30 PM - 3:30 PM in 150 Columbia Hall

• 2:30 PM Joe Wargo - Niell Lab (ION)
• 2:45 PM Danielle Alonzo - Huxtable (Human Phys)
• 3:00 PM Jeremy Guenza-Marcus - McCormick (ION)
• 3:15 PM Brooke Frohock - Gardner (Knight Campus)

Organisms continually tune their perceptual systems to the features they encounter in their environment. We have studied how this experience reorganizes the synaptic connectivity of neurons in the olfactory cortex of the mouse. We developed an approach to measure synaptic connectivity in vivo, training a deep convolutional network to reliably identify monosynaptic connections from the spike-time cross-correlograms of 4.4 million single-unit pairs. This revealed that excitatory piriform neurons that respond similarly to each other are more likely to be connected. We asked whether this like-to-like connectivity was modified by experience but found no effect. Instead, we found a pronounced effect of experience on the connectivity of inhibitory interneurons. Following repeated encounters with a set of odorants, inhibitory neurons that responded differentially to these stimuli both received and formed a high degree of synaptic connections with the cortical network. The experience-dependent organization of inhibitory neuron connectivity was independent of the tuning of either their pre- or their postsynaptic partners. These results suggest the existence of a cell-intrinsic, non-Hebbian plasticity mechanism that depends only on the odor tuning of the inhibitory interneuron. A computational model of this plasticity mechanism predicts that it increases the dimensionality of the entire network’s responses to familiar stimuli, thereby enhancing their discriminability. We confirmed that this network-level property is present in physiological measurements, which showed increased dimensionality and separability of the evoked responses to familiar versus novel odorants. Thus a simple, cell-intrinsic plasticity mechanism acting on inhibitory interneurons may implement a key component of perceptual learning: enhancing an organism’s discrimination of the features particular its environment. [Work with Andrew Fink and Samuel Muscinelli]

www.carlschoonover.com

Catch up on the latest ION research. Enjoy delicious food provided by Tasty Thai Kitchen, and great conversation provided by your fellow neuroscientists. Bring the family!

For more details & a link to RSVP please see the ion mailing list announcement.

Hello all!

Gender Inclusion in Neuroscience (GiiN) is hosting a Rotation 101 workshop on November 27th 10-11am in LISB 317! We will be discussing what is expected of a rotation talk and general tips on how to prepare and present. We welcome any and all first years to attend! If you would like to give a practice talk during the workshop, please send an email to ksuzuki@uoregon.edu. Snacks will be provided!

Glaser Lab website