Upcoming Events!
Abstract: Dexterous movement is a hallmark of human motor ability, enabling us to interact skillfully with our environment. The loss of this capability due to movement disorders, such as Parkinson’s disease or stroke, strips individuals of independence and quality of life. This talk explores the neural underpinnings of dexterity, focusing on how the nervous system integrates sensory and motor signals to achieve precise control. We then examine how these mechanisms break down in movement disorders, leading to impaired motor function. Finally, we turn to neuroengineering technologies which aim to restore movement in affected individuals. By leveraging advances in neural interfaces and wearable systems, we are seeking to design systems to repair motor function. Overall, we highlight our highly interdependent scientific and translational goals to understand and restore complex movement.
In this talk, I will examine the computational motivations and empirical evidence for spatiotemporal dopamine (DA) waves that support reward learning within fronto-striatal networks. I will focus on the cognitive striatum as a case study to show that DA waves tailor decision signals according to local computational/behavioral specialty-- accomplished via vector-weighting delays in DA pulses across space and time. This code resolves key computational challenges in competing C-BG mixture of experts: spatiotemporal credit assessment at reward, and dynamic reprioritization of circuit inference and gating during performance. Ultimately, these DA wave dynamics represent an empirically informed revision of the longstanding "global broadcast" hypothesis of DA RPE signals. Finally, I will briefly summarize our recent attempts at understanding the complexity of the DA wave manifold, and competitive/collaborative circuit interactions that constrain DA to motif trajectories during specific task demands.
2025 UO Undergraduate Research Symposium
Undergraduates, register by April 17, 2025 to present!
Past Events
Studying the neural basis of prey catching behavior across species for over 60 years has...
Studying the neural basis of prey catching behavior across species for over 60 years has significantly advanced our understanding of the most conserved aspects of visual system function. Our team builds upon this important foundation to understand how fundamental visual processes, such as motion-triggered visual orienting, evolve across species and are modulated within species by life-stage and/or reproductive status. Towards this goal, we primarily study the neural basis of motion- and prey-triggered natural visual orienting behavior in the mouse model. Our specific aims are to understand the neural circuit subcortical mechanisms that critically regulate adaptive variations in these behaviors that depend on developmental stage, sex and hunger drive. Predatory behaviors and related visual orienting, are strategically regulated across species by these internal “states” in particular across a broad range of species from birds and bats to primates.
Mice rely on their sense of smell to locate food, attract mates, and evade predators. I will briefly...
Mice rely on their sense of smell to locate food, attract mates, and evade predators. I will briefly discuss how odor identity and intensity are encoded in the mouse olfactory (piriform) cortex and how these representations remain consistent across concentrations, focussing on the neural circuit mechanisms that underlie these operations. Then, I will share recent findings from our lab that reveal how respiration coordinates all cortical odor responses, uncovering a novel framework for the logic of cortical odor coding.