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Abstract: “A central goal shared by neuroscience and robotics is to understand how systems can navigate and act autonomously in complex environments. Although extensive research has revealed how the visual system segments natural scenes into distinct components—insights that have inspired advances in computer vision and robotics—the next crucial challenge remains: learning the properties of these objects and responding appropriately. In this talk, I will present our work using the fruit fly Drosophila melanogaster to investigate how the brain learns about objects and other animals in its environment, and how it uses that information to guide behavior. By integrating quantitative behavioral analysis, genetic manipulation, connectomics, and neural recordings, we aim to uncover the neural mechanisms that enable flexible, adaptive interactions with the world.”
The ION Retreat is scheduled for Saturday September 27 at Noon (including lunch and dinner with guest speaker Anna Gillespie speaking at after dinner. The retreat continues on Sunday September 28 from 9am to noon with brunch.
RSVP for the retreat from the ION mailing list announcement. Contact host Matt Smear for more details.
This is a reschedule remote seminar for Eugenia's seminar from May 8. Contact ionseminars@uoregon.edu to receive the zoom link if not on regular mailing lists with your uoregon email address.
This visit is postponed for 5/29 and we hope to reschedule in the 2025-26 academic year.
Abstract - The superior colliculus (SC) is an evolutionarily conserved structure that receives direct retinal input in all vertebrates. It was the most sophisticated visual center until the neocortex evolved in mammals. Even in mice and tree shrews, mammalian species that are increasingly used in vision research, the vast majority of retinal ganglion cells project to the SC, making it a prominent visual structure in these animals. In this talk, I will review our recent functional studies of the mouse SC and describe our current efforts in linking functional properties to genetically identified cell types in both mice and tree shrews.
2025 UO Undergraduate Research Symposium
Undergraduates, register by April 17, 2025 to present!
A fundamental challenge to understanding the brain is its complexity: its genetic and developmental programs, its neurons and connections, its balance of permanence and plasticity, and the nuanced information flow through its networks. Across biology, emerging technologies are revolutionising the scope and scale at which we can address such questions. Our group has developed technologies for studying brain-wide sensory networks using calcium imaging and house-built light-sheet microscopes. Because zebrafish larvae are small and transparent, we can image tens of thousands of neurons, simultaneously and individually, as animals perceive and respond to sensory stimuli. We have used this approach to produce the first functional maps, brain-wide at cellular resolution, for auditory, vestibular, and water flow perception in a vertebrate. Our lab and others have also used such baseline descriptions as a departure point for exploring altered sensory networks in zebrafish models of neuropsychiatric conditions such as autism.
These imaging studies have taught us where and when neurons are active, but not how or why. In this talk, I will review our calcium imaging approaches and results, and will then discuss how other technologies, such as X-ray diffraction, electron microscopy, and spatial transcriptomics can provide complementary information about the structure and function of brain-wide networks. I will present preliminary data using these platforms and discuss the enormous potential that such combined approaches hold, but also the technical challenges that merging these big-data modalities presents.