For the 2020-2021 academic year, ION seminars are held remotely at either 12 PM or 4 PM PT on Thursdays unless otherwise specified. Seminars are hosted on Zoom and are open to the UO community and occasionally on World Wide Neuro. Links to the weekly seminar will be advertised through the ION mailing list and those not on the list can request access by contacting Jenna Penny at seminars @ uoneuro.uoregon.edu. For more information and support for using the Zoom platform visit UOregon Zoom.
Upcoming Institute of Neuroscience Seminar
Xiaoxuan Jia, PhD
Senior Scientist
Allen Institute
"Tracking information flow in mouse visual areas"
Host: Luca Mazzucato
Thursday, April 15th, 2021 at 12 PM PDT
Zoom access provided via ION mailing list
The anatomy of the mouse visual system indicates it is organized hierarchically, yet direct functional evidence is still lacking. Here, we simultaneously recorded spiking activity from tens of thousands of neurons from six cortical and two thalamic regions along the anatomically defined visual hierarchy in awake mice. Using cross-correlation analysis, we reveal that the organization of inter-area functional connectivity during visual stimulation mirrors the anatomical hierarchy. We find that four classical hierarchical measures —response latency, receptive field size, receptive field complexity, and response decay timescale—are all correlated with the hierarchy. Moreover, recordings during a visual change-detection task reveal that the correlation between neural activity and behavioral choice increases along the hierarchy. These results suggest a functional hierarchy that follows anatomy during sensory drive, which forms the first principle of functional organization in mouse visual system. However, since there are extensive recurrent connections between areas, the signal flow is not a simple one-way pass along the hierarchy. We generated multi-area, directed graphs with single-neuron resolution by analyzing millisecond-timescale leading and lagging spike-timing relationships between pairs of neurons. Network analysis revealed two spatially-distributed functional modules. These modules differ in their layer and area distributions, network properties, individual and population-level temporal dynamics, suggesting they mediate different stages of sensory processing. One module is positioned to transmit feedforward sensory signals along the hierarchy, while the other receives convergent input and engages in recurrent processing. These results reveal a cellular-resolution cortical network topology with distinct sensory processing modules mediating feedforward and recurrent processes, which forms the second principle of functional organization in mouse visual areas.
Spring 2021
DATE | SPEAKER | TITLE | HOST |
---|---|---|---|
4/1/2021 |
Bernado Sabatini | Circuits of action selection and reinforcement | Denver Ncube |
4/8/2021 4 PM PT |
Nicoladie Tam | How to speed up the brain, how emotions bias decisions, is ignorance bliss, is love priceless, gender-difference in emotional sensitivity, and decode movement directions by applying computational theories and analyses of cortical optical imaging hemodynamic signals | Kelsey Schultz |
4/15/2021 12 PM PT |
Xiaoxuan Jia | Tracking information flow in mouse visual areas | Luca Mazzucato |
4/22/2021 12 PM PT |
Fanny Cazettes | Multiplexed accumulation of evidence in the mouse frontal cortex | Luca Mazzucato |
4/29/2021 | Michael Granato | TBA | Sarah Ackerman & Judith Eisen |
5/6/2021 12 PM PT |
Marla Feller | Wiring up direction selective circuits in the retina | Adam Miller |
5/13/2021 12 PM PT |
Gerry Downes | From swimming to seizures: Investigating locomotor behavior and epilepsy in developing zebrafish | Anne Martin |
5/20/2021 | Kang Shen | TBA | Sarah Ackerman |
5/27/2021 | Patrick Kanold | TBA | Santiago Jaramillo |
6/3/2021 | SueYeon Chung | TBA | Luca Mazzucato |
6/10/2021 | Marta Zlatic | CSN Fest - Finals Week | Emily Heckman |
Fall 2020
DATE | SPEAKER | TITLE | HOST |
---|---|---|---|
10/22/2020 Noon PT |
Eve Marder | Mind-Brain Institute of Neurosicence Lecture: "Differential Resilience to Pertubations of Circuits with Similar Performance" | David McCormick |
10/29/2020 12 PM PT |
Cody Smith | Glial and Neuronal Interactions that Build the Nervous System | Judith Eisen |
11/5/2020 12 PM PT |
Georg Keller | Cortical circuits for predictive processing | David McCormick |
11/12/2020 12 PM PT |
Phyllis Robinson | Best Practices in Cultivating Success for Underrepresented Populations Pursuing Degrees in Stem in Higher Education | Judith Eisen DEI |
11/19/2020 12 PM PT |
David McLean | Decoding neural circuits for movement control by studying zebrafish | James Murray |
11/26/2020 | No Seminar - Thanksgiving Holiday | ||
12/3/2020 12 PM PT |
Vanessa Ruta | Theme and Variations: Circuit Mechanisms of Behavioral Evolution | Emily Heckman Womxn in Neuroscience |
12/10/2020 | No Seminar - Finals Week |
Winter 2021
DATE | SPEAKER | TITLE | HOST |
---|---|---|---|
1/14/2021 4 PM PT |
Matthieu Louis | Neural computations directing orientation behavior during larval chemotaxis | Matt Smear |
1/21/2021 Postponed |
Sonja Hofer | Postponed | David McCormick |
1/28/2021 12 PM PT |
Amy Orsborn | Measuring, modeling and shaping neural plasticity in brain-machine interfaces | James Murray |
2/4/2021 | No Seminar - Graduate Recruitment | ||
2/11/2021 12 PM PT |
Sheena Josselyn | Making memories in mice | Dasa Zeithamova |
2/18/2021 Postponed |
Caleb Kemere | Postponed: Latent Spaces of Memory in Real and Virtual Worlds | Cris Niell |
2/25/2021 12 PM PT |
Maria Geffen | The role of cortical adaptation and plasticity in auditory learning and behavior | Isabella Salinas Womxn in Neuroscience |
Wednesday 3/3/2021 10 AM PT |
Kaela Singleton | Control of Neuron Formation in Neurodevelopmental & Neurodegernative Disorders Womxn in Neuroscience hosted seminar |
Rachel Lukowicz |
3/4/2021 4 PM PT |
Melissa Warden | Neuromodulation and the balance between goal-directed and reactive behavior | Emily Sylwestrak |
3/11/2021 12 PM PT |
Richard Mooney | From Song to Synapse | Santiago Jaramillo |
3/18/2021 | No Seminar - Finals Week |
OTHER SEMINARS OF INTEREST
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Institute of Neuroscience Seminar Archive Winter 2016 - Present