ION Seminar Series

For the 2020-2021 academic year, ION seminars are held remotely at either 12 PM or 4 PM PT on Thursdays unless otherwise specified.  Seminars are hosted on Zoom and are open to the UO community and occasionally on World Wide Neuro.  Links to the weekly seminar will be advertised through the ION mailing list and those not on the list can request access by contacting Jenna Penny at seminars @ uoneuro.uoregon.edu. For more information and support for using the Zoom platform visit UOregon Zoom.

 

Upcoming Institute of Neuroscience Seminar

Kang Shen, PhD

Professor of Biology and of Pathology
Stanford University

"Synaptic active zone assembly requires scaffold molecule phase separation"

Host:  Sarah Ackerman

Thursday, May 20th, 2021 at 12 PM PDT

Zoom access provided via ION mailing list

The formation of synapses during neuronal development is essential for establishing neural circuits and a nervous system1. Every presynapse builds a core 'active zone' structure, where ion channels cluster and synaptic vesicles release their neurotransmitters2. Although the composition of active zones is well characterized2,3, it is unclear how active-zone proteins assemble together and recruit the machinery required for vesicle release during development. Here we find that the core active-zone scaffold proteins SYD-2 (also known as liprin-α) and ELKS-1 undergo phase separation during an early stage of synapse development, and later mature into a solid structure. We directly test the in vivo function of phase separation by using mutant SYD-2 and ELKS-1 proteins that specifically lack this activity. These mutant proteins remain enriched at synapses in Caenorhabditis elegans, but show defects in active-zone assembly and synapse function. The defects are rescued by introducing a phase-separation motif from an unrelated protein. In vitro, we reconstitute the SYD-2 and ELKS-1 liquid-phase scaffold, and find that it is competent to bind and incorporate downstream active-zone components. We find that the fluidity of SYD-2 and ELKS-1 condensates is essential for efficient mixing and incorporation of active-zone components. These data reveal that a developmental liquid phase of scaffold molecules is essential for the assembly of the synaptic active zone, before maturation into a stable final structure.

Learn more

 

Spring 2021

DATE SPEAKER TITLE HOST

4/1/2021
12 PM PT

Bernado Sabatini Circuits of action selection and reinforcement Denver Ncube
4/8/2021
4 PM PT
Nicoladie Tam How to speed up the brain, how emotions bias decisions, is ignorance bliss, is love priceless, gender-difference in emotional sensitivity, and decode movement directions by applying computational theories and analyses of cortical optical imaging hemodynamic signals Kelsey Schultz
4/15/2021
12 PM PT
Xiaoxuan Jia Tracking information flow in mouse visual areas Luca Mazzucato
4/22/2021
12 PM PT
Fanny Cazettes Multiplexed accumulation of evidence in the mouse frontal cortex Luca Mazzucato
4/29/2021
12 PM PT
Michael Granato Probing nervous system plasticity using zebrafish Sarah Ackerman & Judith Eisen
5/6/2021 
12 PM PT
Marla Feller Wiring up direction selective circuits in the retina Adam Miller
5/13/2021
12 PM PT
Gerry Downes From swimming to seizures: Investigating locomotor behavior and epilepsy in developing zebrafish Anne Martin
5/20/2021
12 PM PT
Kang Shen Synaptic active zone assembly requires scaffold molecule phase separation Sarah Ackerman
5/27/2021 Patrick Kanold TBA Santiago Jaramillo
6/3/2021 SueYeon Chung TBA Luca Mazzucato
6/10/2021
1 PM PT
Marta Zlatic How we learn, predict and decide: the circuit basis of behaviour Emily Heckman
6/11/2021
1 PM PT
  CSN Fest with Dr. Marta Zlatic  

Fall 2020

DATE SPEAKER TITLE HOST
10/22/2020
Noon PT
Eve Marder Mind-Brain Institute of Neurosicence Lecture:  "Differential Resilience to Pertubations of Circuits with Similar Performance David McCormick
10/29/2020
12 PM PT
Cody Smith Glial and Neuronal Interactions that Build the Nervous System Judith Eisen
11/5/2020
12 PM PT
Georg Keller Cortical circuits for predictive processing David McCormick
11/12/2020
12 PM PT
Phyllis Robinson Best Practices in Cultivating Success for Underrepresented Populations Pursuing Degrees in Stem in Higher Education Judith Eisen
DEI
11/19/2020 
12 PM PT
David McLean Decoding neural circuits for movement control by studying zebrafish James Murray
11/26/2020   No Seminar - Thanksgiving Holiday  
12/3/2020
12 PM PT
Vanessa Ruta Theme and Variations: Circuit Mechanisms of Behavioral Evolution Emily Heckman
Womxn in Neuroscience
12/10/2020   No Seminar - Finals Week  

Winter 2021

DATE SPEAKER TITLE HOST
1/14/2021
4 PM PT
Matthieu Louis Neural computations directing orientation behavior during larval chemotaxis Matt Smear
1/21/2021
Postponed
Sonja Hofer Postponed David McCormick
1/28/2021
12 PM PT
Amy Orsborn Measuring, modeling and shaping neural plasticity in brain-machine interfaces James Murray
2/4/2021   No Seminar - Graduate Recruitment  
2/11/2021
12 PM PT
Sheena Josselyn Making memories in mice Dasa Zeithamova
2/18/2021 
Postponed
Caleb Kemere Postponed: Latent Spaces of Memory in Real and Virtual Worlds Cris Niell
2/25/2021
12 PM PT
Maria Geffen The role of cortical adaptation and plasticity in auditory learning and behavior Isabella Salinas
Womxn in Neuroscience
Wednesday
3/3/2021
10 AM PT
Kaela Singleton Control of Neuron Formation in Neurodevelopmental & Neurodegernative Disorders
Womxn in Neuroscience hosted seminar
Rachel Lukowicz
 
3/4/2021
4 PM PT
Melissa Warden Neuromodulation and the balance between goal-directed and reactive behavior Emily Sylwestrak
3/11/2021
12 PM PT
Richard Mooney From Song to Synapse Santiago Jaramillo
3/18/2021   No Seminar - Finals Week