Associate Professor, Department of Psychology
Ph.D. California Institute of Technology
Sc.B. Brown University
Research Interests: How local circuits in the auditory cortex encode and transform sensory information
Overview: We study how local circuits in the cerebral cortex encode and transform sensory information. We use the rodent auditory cortex as a model system to investigate how cellular and network properties shape cortical responses to a continuous and temporally complex stream of sensory data. Research in my laboratory combines aspects of both cellular, systems, and computational neuroscience, by using the tools of molecular biology and cellular physiology to address systems-level questions. By using a variety of electrophysiological approaches, in particular in vivo whole cell recording methods in combination with molecular manipulations, we are trying to identify the cellular and synaptic mechanisms with which cortical circuits process auditory information, leading ultimately to our perceptual experiences of acoustic streams, such as music and speech.
Gap encoding by parvalbumin-expressing interneurons in auditory cortex.
J Neurophysiol. 2018 Mar 28;:
Authors: Keller CH, Kaylegian K, Wehr M
Synaptic inhibition shapes the temporal processing of sounds in auditory cortex, but the contribution of specific inhibitory cell types to temporal processing remains unclear. Here we recorded from parvalbumin-expressing (PV+) interneurons in auditory cortex to determine how they encode gaps in noise, a model of temporal processing more generally. We found that PV+ cells had stronger and more prevalent on-responses, off-responses, and post-response suppression compared to presumed pyramidal cells. We summarize this pattern of differences as "deeper modulation" of gap responses in PV+ cells. Response latencies were also markedly faster for PV+ cells. We found a similar pattern of deeper modulation and faster latencies for responses to white noise bursts, suggesting that these are general properties of on- and off-responses in PV+ cells rather than specific features of gap encoding. These findings are consistent with a role for PV+ cells in providing dynamic gain control by pooling local activity.
PMID: 29589814 [PubMed - as supplied by publisher]