Michael Wehr

Associate Professor, Department of Psychology
Member, ION

Ph.D. California Institute of Technology
Sc.B. Brown University

Office:
LISB 213
541-346-5866
Lab:
LISB 203-206
541-346-6302

 

Research Interests: How local circuits in the auditory cortex encode and transform sensory information

Overview: We study how local circuits in the cerebral cortex encode and transform sensory information. We use the rodent auditory cortex as a model system to investigate how cellular and network properties shape cortical responses to a continuous and temporally complex stream of sensory data. Research in my laboratory combines aspects of both cellular, systems, and computational neuroscience, by using the tools of molecular biology and cellular physiology to address systems-level questions. By using a variety of electrophysiological approaches, in particular in vivo whole cell recording methods in combination with molecular manipulations, we are trying to identify the cellular and synaptic mechanisms with which cortical circuits process auditory information, leading ultimately to our perceptual experiences of acoustic streams, such as music and speech.

RECENT PUBLICATIONS

Related Articles

Gap encoding by parvalbumin-expressing interneurons in auditory cortex.

J Neurophysiol. 2018 Mar 28;:

Authors: Keller CH, Kaylegian K, Wehr M

Abstract
Synaptic inhibition shapes the temporal processing of sounds in auditory cortex, but the contribution of specific inhibitory cell types to temporal processing remains unclear. Here we recorded from parvalbumin-expressing (PV+) interneurons in auditory cortex to determine how they encode gaps in noise, a model of temporal processing more generally. We found that PV+ cells had stronger and more prevalent on-responses, off-responses, and post-response suppression compared to presumed pyramidal cells. We summarize this pattern of differences as "deeper modulation" of gap responses in PV+ cells. Response latencies were also markedly faster for PV+ cells. We found a similar pattern of deeper modulation and faster latencies for responses to white noise bursts, suggesting that these are general properties of on- and off-responses in PV+ cells rather than specific features of gap encoding. These findings are consistent with a role for PV+ cells in providing dynamic gain control by pooling local activity.

PMID: 29589814 [PubMed - as supplied by publisher]

Related Articles

Rapid Rebalancing of Excitation and Inhibition by Cortical Circuitry.

Neuron. 2018 Feb 16;:

Authors: Moore AK, Weible AP, Balmer TS, Trussell LO, Wehr M

Abstract
Excitation is balanced by inhibition to cortical neurons across a wide range of conditions. To understand how this relationship is maintained, we broadly suppressed the activity of parvalbumin-expressing (PV+) inhibitory neurons and asked how this affected the balance of excitation and inhibition throughout auditory cortex. Activating archaerhodopsin in PV+ neurons effectively suppressed them in layer 4. However, the resulting increase in excitation outweighed Arch suppression and produced a net increase in PV+ activity in downstream layers. Consequently, suppressing PV+ neurons did not reduce inhibition to principal neurons (PNs) but instead resulted in a tightly coordinated increase in both excitation and inhibition. The increase in inhibition constrained the magnitude of PN spiking responses to the increase in excitation and produced nonlinear changes in spike tuning. Excitatory-inhibitory rebalancing is mediated by strong PN-PV+ connectivity within and between layers and is likely engaged during normal cortical operation to ensure balance in downstream neurons.

PMID: 29503186 [PubMed - as supplied by publisher]